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Membrane Anchored hRANKL Cell

CBP74160

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I. Background
The receptor activator of NF-κB ligand (RANKL) and its receptor RANK are critical regulators for immune responses as well as bone remodeling. RANKL is a type II transmembrane protein that has two forms—a membrane-anchored protein and a secreted protein.The membrane form of RANKL was also expressed on the infiltrating T cells in the rheumatoid synovial fluid and in the gingival tissues of patients with periodontitis.
 
II. Introduction
Expressed gene: Membrane Anchored hRANKL
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: F12K+10%FBS+5ug/ml puromycin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Functional(Report Gene) Assay
 
III. Representative Data

Figure 1. Membrane Anchored hRANKL Cell flow cytometry data.

 

Figure 2. Dose response of hRANKL Ab in ADCC Bioassay Effector Cell (High Affinity/NFAT-Jurkat cells) With Membrane Anchored hRANKL Cells (Clone 12).

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