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STK11 p.KP178fs Reference Standard

CBP10465

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Introduction 
Gene STK11
Description STK11, serine/threonine kinase 11, is a tumor suppressor (PMID: 30562755) involved in cell metabolism, growth, polarity, and tumor suppression through the regulation of AMPK family members (PMID: 26398719). STK11 germline mutations are common in Peutz-Jeghers syndrome and somatic STK11 mutations have been identified in melanoma, lung, pancreatic, cervical, and endometrial cancers (PMID: 26877140, PMID: 29191602) and are often associated with resistance to immune checkpoint blockcade (PMID: 30626603).
   
Technical Data 
DNA Change c.532_536delAAGCC
AA Change p.KP178fs
Mutation type Frame_Shift_Del
Zygosity Homozygous
Allelic Frequency 100.00%
Transcript ENST00000326873.7
Cosmic ID N/A
Chr position(GRCh37) chr19:1220439_1220443
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing  
Storage 2-8℃
Expiry 36 months from the date of manufacture

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