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EZH2 p.Y646F Reference Standard

CBP10276

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产品数据库
Introduction 
Format Genomic DNA
Description EZH2 Y646F (corresponds to Y641F in the canonical isoform) lies within a SET domain of the Ezh2 protein (UniProt.org). Y646F confers a gain of function to the Ezh2 protein, as demonstrated by altered substrate specificity and increased catalytic efficiency for H3K27 trimethylation (PMID: 21190999, PMID: 24563539).
   
Technical Data 
DNA Change c.1937A>T
AA Change p.Y646F
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 33.33%
Transcript ENST00000320356
Cosmic ID COSM37028
Chr position(GRCh37) chr7:148508727
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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