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CDK12 p.Q1088* Reference Standard

CBP10541

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Introduction 
Format Genomic DNA
Description CDK12, cyclin dependent kinase 12, is a key regulator of transcription elongation, regulates the expression of genes involved in DNA repair, and is required for the maintenance of genomic stability (PMID: 24554720; PMID: 22012619). Loss and/or inactivation of CDK12 has been commonly observed in many solid tumor types, including prostate (PMID: 29906450, PMID: 31640893), breast, ovarian, endometrial, uterine (PMID: 30104286), and is a likely tumor suppressor (PMID: 30319007).
   
Technical Data 
DNA Change: c.3262C>T
AA Change p.Q1088*
Mutation type Nonsense_Mutation
Zygosity Heterozygous
Allelic Frequency 33.33%
Transcript NM_016507.4
Cosmic ID COSM472690
Chr position(GRCh37) chr17:37681093
Buffer: Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8°C
Expiry 36 months from the date of manufacture

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